Anchoring immunosuppression to inflamed tissue
Graphical abstract commisioned by Dr. Gabriel Rabinovich
Laboratorio de Glicomedicina Instituto de Biología y Medicina Experimental (IBYME) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) Vuelta de Obligado 2490 C1428- Ciudad de Buenos Aires ARGENTINA TE: +54-11-4783-2869 (ext. lab: 236) (ext office: 266 or 269) Fax: +54-11-4786-2564 E-mail: gabyrabi@gmail.com E-mail: gabriel.r@ibyme.conicet.gov.ar
Fusing the anti-infammatory enzyme indoleamine 2,3-dioxygenase to the tissue-anchoring protein galectin-3 ameliorates infammation at the injection site while avoiding systemic immune suppression, as shown in multiple rodent models of infammation.
