Cyanovirin-N (CV-N) is a protein produced by the cyanobacterium Nostoc ellipsosporum that displays virucidal activity against several viruses, including human immunodeficiency virus (HIV). The virucidal activity of CV-N is mediated through specific high-affinity interactions with the viral surface envelope glycoproteins gp120 and gp41, as well as to high-mannose oligosaccharides found on the HIV envelope. In addition, CV-N is active against rhinoviruses, human parainfluenza virus, respiratory syncytial virus, and enteric viruses. The virucidal activity of CV-N against influenza virus is directed towards viral haemagglutinin. CV-N has a complex fold composed of a duplication of a tandem repeat of two homologous motifs comprising three-stranded beta-sheet and beta-hairpins. Here you can see a domain-swapped structure of cyanovirin N from the cyanobacteria Nostoc ellipsosporum determined by X-ray crystallography (PDB code: 1L5B)
#molecularart ... #immolecular ... #cyanovirin ... #antiviral ... #cyanobacteria ... #nostoc ... #domainswapping ... #xray
Rendered with @proteinimaging and polished with @corelphotopaint
#molecularart ... #immolecular ... #cyanovirin ... #antiviral ... #cyanobacteria ... #nostoc ... #domainswapping ... #xray
Rendered with @proteinimaging and polished with @corelphotopaint
